Correction: Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding
نویسندگان
چکیده
This is a correction article.After publication of this work [1], we became aware of the fact that Robert C. Speth was notincluded as an author. Dr. Speth put a considerable amount of time and effort into developing andpreparing the radiopeptide used to carry out the radioligand binding studies reported in thismanuscript and therefore should have originally been included as an author. We apologize to Dr.Speth for any inconvenience that this oversight might have caused and thank him for his invaluablecontribution to this project. References1. Banerjee S, Evanson J, Harris E, Lowe SL, Thomasson KA, Porter JE:Identification of specific calcitonin-like receptor residuesimportant for calcitonin gene-related peptide high affinitybinding. BMC Pharmacology 2006, 6:9.Published: 06 December 2006BMC Pharmacology 2006, 6:14 doi:10.1186/1471-2210-6-14Received: 05 December 2006Accepted: 06 December 2006 This article is available from: http://www.biomedcentral.com/1471-2210/6/14© 2006 Banerjee et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
منابع مشابه
Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding
BACKGROUND Calcitonin gene-related peptide (CGRP) is a vasoactive neuropeptide whose biological activity has potential therapeutic value for many vascular related diseases. CGRP is a 37 amino acid neuropeptide that signals through a G protein-coupled receptor belonging to the secretin receptor family. Previous studies on the calcitonin-like receptor (CLR), which requires co-expression of the re...
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The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity-modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. There have been few systematic studies of the ECLs (extracellular loops) of family B G...
متن کاملThe role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach
The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1. The role of the second extracellular loop (ECL2) of CLR in binding CGRP and coupling to Gs was investigated using a combination of mutagenesis and modelling. An alanine scan of residues 271...
متن کاملStructure–activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation
BACKGROUND AND PURPOSE The N-terminus of calcitonin gene-related peptide (CGRP) is important for receptor activation, especially the disulphide-bonded ring (residues 1-7). However, the roles of individual amino acids within this region have not been examined and so the molecular determinants of agonism are unknown. This study has examined the role of residues 1, 3-6 and 8-9, excluding Cys-2 and...
متن کاملInteraction of calcitonin-gene-related peptide with its receptors.
The receptor for calcitonin-gene-related peptide (CGRP) is a heterodimer formed by calcitonin-receptor-like receptor (CRLR), a type II (family B) G-protein-coupled receptor, and receptor-activity-modifying protein 1 (RAMP1), a single-membrane-pass protein. It is likely that the first seven or so amino acids of CGRP (which form a disulphide-bonded loop) interact with the transmembrane domain of ...
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عنوان ژورنال:
- BMC Pharmacology
دوره 6 شماره
صفحات -
تاریخ انتشار 2006